Wiwi Mardiah, Irman Somantri, Siti Zulfa


Background: Pain is a subjective, emotionally unpleasant and individualized sensation, which affects both actual and potential tissue damage. This individual pain is expressed through various levels: mild, moderate and severe pain. Pain that is often experienced by infants such as pain caused by Pentabio invasive immunization action. One of the nursing interventions in reducing pain in infants before pentabio immunization is with a 24% sucrose or sucrose solution 75% two minutes before the action. Sucrose is a medium that will stimulate the secretion of endorphins to reduce pain. Objectives: The purpose of this study was to determine the relationship of pain level to endorphin secretion in infants who received Pentabio immunization. Methods: The research method used was quasi experiment with correlation approach, to measure pain scale using NIPS Scale, descriptive data analysis for sub variable using univariate analysis and bivariate analysis with T test, to know endorphin level after sucrose administration was done ELISA examination, from baby saliva. The number of samples in this study were 30 samples with purposive samples. Results: The results, based on Mann Whitney test obtained the average value for mild pain scale 13.2569 and average value of moderate pain scale 14.1079 with p- value 0.545. This suggests that there is no significant relationship between the pain scales experienced for endorphin secretion but there is a difference in the amount of secretion on the larger pain scale compared with the mild pain scale. Conclusions: so it can be concluded that the secretion of endorphins will always be secreted when the baby gets a good response with mild or moderate scale pain. It is recommended to continue to give a sucrose solution because there is an increase in the secretion of endorphin even in small amounts.


endorphins, immunization.pentabio

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Adam S Sprouse-Blum ,Greg Smith, Daniel Sugai et al,2010 Understanding Endorphins and Their Importance in Pain Management

Carole Wade,Carol Tavris, 2013.Psikologi Edisi 9, Jilid 1 hal 125, Penerbit Erlangga

Darwin, Philips. (2013). Menikmati Gula Tanpa Rasa Takut. Perpustakaan Nasional: Sinar IlmuYogyakarta

Hasan Sahebihagh, Mohammad et al. 2010. The effect of breastfeeding, oral sucrose and combination of oral sucrose and breastfeeding in infant’s pain relief during vaccination. IJNMR/Winter 2011, 16 (1):1-7

Linda,A et al. 2008. Analgesic Properties of Oral Sucrose During Routine Immunizations at 2 and 4 Months of Age. Pediatrics, 121:e327

Minarti. Aries, Damayanthi Pande Dewi,2013, Pengaruh Pemberian Oral Sukrosa Terhadap Intensitas Nyeri Saat Imunisasi Dpt-Hb (Dpt Combo) Pada Bayi Di Puskesmas Ii Denpasar Timur

Kristiawati, Krisna Yetti, Hening Pujasari, 2010,Grant Of Sucrose And Non-Nutritive Sucking To Pain Response And The Long Cries Of Neonates To Invasive Procedures,


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